ICAM-4 of red blood cells binds to I domain of some leukocyte integrins.

2003 JUN 19 - (NewsRx.com & NewsRx.net) -- Red blood cells and leukocytes do interact through binding of the ICAM-4 to the I domains of CD11/CD18 integrins.

"Intercellular adhesion molecule-4 (ICAM-4, LW blood group antigen), a member of the immunoglobulin superfamily expressed on red cells, has been reported to bind to CD11a/CD18 and CD11b/CD18 leukocyte integrins.

"The location of the ICAM-4 binding sites on CD11a/CD18 and CD11b/CD18 are not known. CD11/CD18 integrin I domains have been found to act as major binding sites for physiological ligands and a negatively charged glutamic acid in ICAMs is considered important for binding," scientists in Finland …